L-lactide ring-opening polymerization on a magnesium catalyst based on acenaphthene-1,2-diimine ligand: Development of biocompatible materials for osteoplasty

Isotactic poly-L-lactide was prepared by L-lactide ring-opening polymerization in tetrahydrofuran solution in the presence of a magnesium complex derived from 1,2-bis-[(2,6-diisopropyl)phenylimino]acenaphthene (dpp-bian). Polymer specimens in the form of cylindrical blocks, prepared by hot molding, were tested in experiments with human dermal fibroblast cultures. The polymers prepared exhibit no cytotoxicity, which opens prospects for performing their preclinical animal tests.