PECULIARITIES OF ERYTHROPOIETIN SYNTHESIS CIRCADIAN RHYTHM IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION

Abstract Erythropoietin (ERO) is known to be the main regulator of proliferation and terminal dissociation of erythroid cells. Its receptors are expressed not only in hematopoietic cells but also in the tissues of the cardiovascular system. The aim of this work was to study specific features of circadian rhythm in erythropoietin synthesis and estimate the predictive informative value of serum ERO level variations as regards the risk of developing cardiovascular complications in patients with stage II essential arterial hypertension (EAH). ERO, neopterin, and interleukin-1 levels were measured in 200 such patients. It was shown that ERO levels increased (p < 0.001) compared with normal values (12.6 pg/ml, 95% CI 11.8-13.4 and 68 pg/ml, 95% CI 6.4-7.2 respectively). Analysis of circadian rhythm demonstrated that enhanced probability of complications in the absence of reduction of the ERO level at night time correlated with the decreased number of CD34 cells (p < 0.001) and the increased neopterin level (p < 0.001). It is concluded that these dependences suggest the necessity of further studies of yet unknown effects of ERO and ways of their application for the treatment of EAH.