monoclonal anti-human CD40 antibody antagonist

An anti-CD40 antibody comprising a variable light chain region and a variable region cadenapesada, said variable heavy chain region comprising a sequence aminoacidosen wherein: X1 is ** ** Formula I and X2 is V; X1 is L and X2 is I; X1 is V and X2 is V; X1 is L and X2 is L; or X1 is L and X2 is V; and X3 is G, A, V, L, I, P, F, M, W, C, N, Q, S, T, Y, D, E, K, R or H; X4 is G, A, V, L, I, P, F, M, W, C, N, Q, S, T, Y, D, E, K, R or H; and X5 is G, A, V, L, I, P, F, M, W, C, N, Q, S, T, Y, D, E, K, R or H; and said light chain or variable domain comprising an amino acid sequence.