Retrospective analysis of ocular cicatricial pemphigoid

Objective To analyze the clinical characterization of ocular cicatricial pemphigoid (OCP). Methods It was a retrospective series case study. Five consecutive patients referred for the evaluation of possible OCP from January 2005 to October 2008 in Departments of Ophthalmology and Dermatology of Peking University First Hospital History and clinical characterization of 5 cases ( 10 eyes) OCP having been misdiagnosed were analyzed to find the causes of misdiagnosis. Results All of cases were diagnosed as chronic conjunctivitis during the early stages of the diseases, one case was diagnosed as Stevens-Johnson syndrome and one as Sj(o)gren syndrome during the later stage. It was two to five years from the first time to see a doctor to definite diagnosis. All of cases have been prescribed antibiotic eye drops for a long times, one case has been undergone three times trichiasis operation and made the disease progression.Among the five patients with OCP, 3 eyes were diagnosed Stage Ⅱ , 5 eyes Stage Ⅲ, 2 eyes Stage Ⅳ. Three cases were positive of bacterial culture. Only in 1 case, there was slight increase of iron protein as tumor mark. Inflammation was controlled by the end of the study, but cicatrization of 2 cases still progressed.Conclusion Manifestation of OCP can mimic chronic conjunctivitis during the early stages, it is important to pay high attention to OCP, misdiagnosis may be stopped. Key words: Eye diseases; Pemphigoid,benign mucous membrane; Retrospective studies