elastase inhibitors containing conformationally restricted lactams as P3-P2 dipeptide replacements

Jerry W. Skiles,Ronald John Sorcek,Stephen P. Jacober,Clara K. Miao,Philip W. Mui,Daniel W. McNeil,Alan S. Rosenthal

elastase inhibitors containing conformationally restricted lactams as P3-P2 dipeptide replacements

1993

Jerry W. Skiles
Ronald John Sorcek
Stephen P. Jacober
Clara K. Miao
Philip W. Mui
Daniel W. McNeil
Alan S. Rosenthal

The synthesis of potential human leukocyte elastase (HLE) inhibitors containing conformationally restricted lactams as peptidomimetic replacements at P3-P2 and which contain a trifluoromethyl ketone of valine at P1 are described.

Keywords:

Trifluoromethyl
Human Leukocyte Elastase
Peptidomimetic
Dipeptide
Ketone
Elastase
Valine
Stereochemistry
Organic chemistry
Chemistry
Biochemistry
trifluoromethyl ketone

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