The Association between Serum Uric Acid, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: the role of Age and Vitamin C

The association between UA with FN-BMD and hip bone geometry parameters. » Serum UA levels (per SD increase) were positively associated with FN-BMD (β=0.007 g/cm2, 95%CI=0.002; 0.01). » UA levels were associated with thicker cortices (β=0.002 cm, 95%CI=0.0003; 0.002) lower bone width (β=-0.013 cm, 95%CI=-0.23; -0.003) and lower cortical buckling ratio (β=-0.19, 95%CI=-0.33; -0.06). » The effects of UA on FN-BMD and cortical buckling ratio tended to become stronger over time (per SD increase in UA, there was an annual increase of 0.0003 (95%CI: 0.000; 0.001, P=0.03) and an annual decrease of 0.05 (95%CI: 0.05; -0.002, P=0.048) in FN-BMD and cortical buckling ratio respectively).