Preparation, Evaluation and Characterization of Solid Dispersion of Piroxicam

Piroxicam is a Cycloxygenase-2 (COX-2) inhibitor used as analgesic and anti inflammatory drug. One of the major problems with the drug is that it is practically insoluble in water which results in poor oral bioavailability. In the present work solid dispersions of piroxicam were prepared by using various water soluble carriers to increase its water solubility. We used various water soluble carriers such as polyvinyl pyrrolidone (PVP), polyethylene glycol (PEG)-6000 and PEG-4000 in different ratio. Solid dispersions were subjected to Infrared spectroscopy (IR), Nuclear Magnetic Resonance (NMR), Thin Layer Chromatography (TLC), UV-visible Spectroscopy, Dissolution Studies, solubility studies and percentage drug content were performed. All solid dispersions of piroxicam show higher solubility and faster dissolution than pure drug alone. Piroxicam: PVP (1:5) ratio show highest solubility and faster dissolution than any other solid dispersion.