[Association of polymorphisms of potassium voltage-gated channel, KQT-like subfamily, member 1 and type 2 diabetes in Jiangsu province, China].

Objective To study the association of polymorphisms in the potassium voltage-gated channel,KQT-like subfamily,member 1 (KCNQ1) gene with type 2 diabetes in Chinese population from Jiangsu province.Methods Subjects consisting of 2925 cases and 3281 controls were enrolled from a community based cohort study of type 2 diabetes in Wuxi in 2007 and a community based cross-sectional survey on chronic non-communicable disease in Nantong in 2009.Epidemiological questionnaire survey and physical examinations were conducted and 10 h overnight fasting blood samples of 5 ml were drawn for all subjects.Genotypes were determined by TaqMan OpenArray Genotyping System and i-PLEX Sequenom MassARRAY platform.The relationship between KCNQ1 gene polymorphism and risk of type 2 diabetes after adjustment for age,sex and body mass index (BMI) was analyzed.Results The C allele of rs2237897,rs2237892 and rs2237895 at KCNQ1 increased the risk of type 2 diabetes with adjusted OR (95％ CI) value being 1.41 (1.30-1.54),1.35 (1.24-1.47),1.22 (1.12-1.33) respectively (all P value ＜ 0.05) under the additive genetic model after adjusted by age,sex and BMI.Stratification analyses in additive genetic model showed that the C allele of rs2237897 increased the risk of type 2 diabetes in subgroups stratified by age (≤56 years and ＞56 years),sex (females and males),BMI (＜ 24 kg/m2 and ≥ 24 kg/m2) with OR (95％ CI) value being 1.39 (1.22-1.59),1.43 (1.28-1.60),1.40 (1.26-1.55),1.44(1.26-1.66),1.48 (1.33-1.66),1.34 (1.17-1.53) respectively (all P value ＜ 0.05).Conclusion Polymorphisms of rs2237897,rs2237892 and rs2237895 in the KCNQ1 gene were associated with occurrence of type 2 diabetes among Jiangsu province population. Key words: Genome-wide association study;  Polymorphism, single nucleotide;  Diabetes mellitus,type 2;  KCNQ1 gene