Palmitic Acid-Rich High Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress

Sarah G. Chu,Julian A. Villalba,Xiaoliang Liang,Kevin Xiong,Konstantin Tsoyi,Bonna Ith,Ehab A. Ayaub,Raju V. V. Tatituri,Derek E. Byers,Fong-Fu Hsu,Souheil El-Chemaly,Edy Y. Kim,Yuanyuan Shi,Ivan O. Rosas

Palmitic Acid-Rich High Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress

2019

Sarah G. Chu
Julian A. Villalba
Xiaoliang Liang
Kevin Xiong
Konstantin Tsoyi
Bonna Ith
Ehab A. Ayaub
Raju V. V. Tatituri
Derek E. Byers
Fong-Fu Hsu
Souheil El-Chemaly
Edy Y. Kim
Yuanyuan Shi
Ivan O. Rosas

The impact of lipotoxicity on the development of lung fibrosis is unclear. Saturated fatty acids such as palmitic acid (PA) activate endoplasmic reticulum (ER) stress, a cellular stress response as...

Keywords:

Biochemistry
Endocrinology
Pulmonary fibrosis
Internal medicine
Palmitic acid
Endoplasmic reticulum
Biology
Lung fibrosis
Lipotoxicity
high fat diet
Cellular stress response
CD36

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