PT349 Droplet digital PCR measurement of copy number variation in genome-wide association regions for blood pressure reveal association with essential hypertension

Conclusion: Early treatment of FD with ERT stabilizes cardiac morphology and renal function. If abnormal cardiac parameters have not improved by 2 years on ERT, they are unlikely to respond later. Elevated left ventricular filling pressure, defined by E/Ea >15, identified patients at increased risk of cardiac events. Patients with severe renal disease continue to decline despite ERT and renal transplantation. Disclosure of Interest: A. Talbot Grant/research support from: Shire Corporation, Sanofi Corporation, Amicus Therapeutics, Protalix Biotherapeutics, Honorarium from: Shire Corporation, Sanofi Corporation, N. Lewis: None Declared, K. Nicholls Grant/research support from: Shire Corporation, Sanofi Corporation, Amicus Therapeutics, Protalix Biotherapeutics, Honorarium from: Shire Corporation, Sanofi Corporation, Amicus Therapeutics, Protalix Biotherapeutics