The Emerging Neuroepitranscriptome

Chemical modifications on ribonucleic acid are prominent in the brain, are emerging as regulators of proper brain development, and have been implicated in neurological disorders. Similar to epigenetic modifications that regulate gene expression patterns, epitranscriptomic marks and their associated cellular machinery are involved in the expression of RNA that is required for developmental processes and maintenance of the nervous system. This work provides a detailed view on the current literature surrounding N6-methyladeonosine, N1-methyladeonsine, 5-methylcytidine, pseudouridine, and other RNA modifications in brain development and neurological disorders.