Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53+/− mice and c-myc-3'RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin

Pauline Rouaud 1 , Remi Fiancette 1 , Christelle Vincent-Fabert 1 , Virginie Magnone 2 , Michel Cogne 1 , Pierre Dubus 3 and Yves Denizot 1 1 UMR CNRS 7276, Faculte de Medecine, Limoges, France 2 CNRS and University of Nice Sophia Antipolis, Institut de Pharmacologie Moleculaire et Cellulaire, UMR 6097, Sophia Antipolis, France 3 EA2406, Universite de Bordeaux, Bordeaux, France Received: April 3, 2012; Accepted: April 28, 2012; Published: May 9, 2012; Keywords: Mantle cell lymphoma, c-myc Correspondence: Yves Denizot, email: // // Abstract Mantle cell lymphoma (MCL) is a malignant lymphoproliferative B-cell disorder that does not occur spontaneously in mice but experimental mice model have been developed. Recently two different mice models prone to develop MCL-like lymphomas were generated: c-myc -3’RR/Cdk4 R24C mice and c-myc -3’RR/p53 +/- mice. Comparison of their gene expression profiles does not highlight specific differences other than those in relation with their specific mutational status (i.e., Cdk4 R24C mutation or p53 mutation). We propose that similarly to typical human MCL and its blastoid or cyclin-D1 variants that correspond to the same genetic entity, MCL-like lymphomas of c-myc -3’RR/p53 +/- mice and c-myc -3’RR/Cdk4 R24C mice represent a spectrum of the same entity.