Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles: New Selective Ligands of the 5-HT7 Receptor
2002
Abstract The synthesis and the affinity for the 5-HT 7 receptor and other receptors of a novel series of fused-ring tetrahydropyridine derivatives are described. Some of the compounds showed high affinity for the 5-HT 7 receptor. Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles 5d and 5h are potent ligands for the 5-HT 7 receptor, with high selectivity over the 5-HT 2 receptor and other receptors. These compounds should be useful tools for clarifying the biological role of the 5-HT 7 receptor.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
23
References
33
Citations
NaN
KQI