GABAergic Neuron-related DNA Methylation Modification and Chronic Pain

Chronic pain is one of the major health problems in the world. Studies have shown that chronic pain is closely related to epigenetics. Chronic pain can increased the level of DNA methylation of GABAergic neurons. This article focused on the three aspects: GABAergic neurons and chronic pain, DNA methylation and chronic pain, GABAergic neuron-related DNA methylation modification and chronic pain. Discussion of the mechanism that chronic pain can increase DNA methylation of the GABAergic neuron, may be helpful for improving the clinical efficacy of chronic pain, and guiding clinical medication to improve the quality of life of patients with pain.