Pharmacokinetics of levosimendan and its circulating metabolites in patients with heart failure after an extended continuous infusion of levosimendan

Saila Antila,Matti Kivikko,Lasse Lehtonen,Jaan Eha,Aira Heikkilä,Pasi Pohjanjousi,Pertti J. Pentikäinen

Pharmacokinetics of levosimendan and its circulating metabolites in patients with heart failure after an extended continuous infusion of levosimendan

2004

Saila Antila
Matti Kivikko
Lasse Lehtonen
Jaan Eha
Aira Heikkilä
Pasi Pohjanjousi
Pertti J. Pentikäinen

Aims The purpose of the study was to characterize the pharmacokinetics of levosimendan and its metabolites OR-1855 and OR-1896 in patients with congestive heart failure.

Keywords:

Heart failure
Anesthesia
Metabolite
Levosimendan
Diabetes mellitus
Heart disease
Cardiotonic Agents
Medicine
Pharmacokinetics
Perfusion
Active metabolite

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