Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation

Janet L. Ralbovsky,Joseph Lisko,Jeffrey M. Palmer,John Mabus,Kristen M. Chevalier,Mark Schulz,Alexey B. Dyatkin,Tamara A. Miskowski,Steven J. Coats,Pamela J. Hornby,Wei He

Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation

2009

Janet L. Ralbovsky
Joseph Lisko
Jeffrey M. Palmer
John Mabus
Kristen M. Chevalier
Mark Schulz
Alexey B. Dyatkin
Tamara A. Miskowski
Steven J. Coats
Pamela J. Hornby
Wei He

A series of guanidine triazinediones were identified as potent PK1 receptor antagonists. A compound in this series inhibited the PK1 invoked prosecretory response in rat ileum tissue.

Keywords:

Antagonist
Prokineticin
Chemical synthesis
G protein-coupled receptor
Biochemistry
Prokineticin receptor 1
In vitro
Receptor
Chemistry
Guanidine

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