Discovery of 2-amino-6-carboxamidobenzothiazoles as potent Lck inhibitors.
2008
Abstract A novel series of 2-amino-6-carboxamidobenzothiazole was discovered to have potent Lck inhibitory properties. A highly efficient chemistry was developed. Also described are the detailed SAR study and the BaF3 cell line profiling for this series.
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