Synthesis of Deoxyneo-β-hydroxyaspergillic Acid

Deoxyneo-β-hydroxyaspergillic acid (I), originally isolated from Aspergillus ochraceus WILH., was synthesized from 2-chloro-3, 6-diisolbutylpyrazine (III) through several steps. Methylmagnesium iodide was used for cleavage of the ether bond on the last step.