One-Pot, Pd-Catalyzed Synthesis of trans-Dihydrobenzofurans from o-Aminophenols

An efficient and facile synthesis of trans-dihydrobenzofurans has been accomplished from o-aminophenols and phenylpropenes via a novel (one-pot) diastereoselective Pd-catalyzed oxyarylation reaction. The development and optimization of this method is described.