Sampling apparatus and method for taking a sample from a bioreactor

The invention relates to a sampling device and method for taking a sample from a bioreactor. According to the invention, at least one reactor liquid stream containing microorganisms and brought together a coolant flow at a point and suction filtered through a mixing device. Characterized a maximum cooling is effected in faster time that the metabolic Chemical composition inside the cells of the microorganisms and in the reactor liquid change less than in the prior art, or not change in the ideal case and the metabolic state of the cell to be examined at a desired time can. In particular, it is possible to determine the chemical composition after addition of a material component to the reactor liquid.