НАРУШЕНИЕ МИКРОБИОЦЕНОЗА КИШЕЧНИКА КАК ФАКТОР ФОРМИРОВАНИЯ ПОСТИНФЕКЦИОННОЙ ПАТОЛОГИИ ОРГАНОВ ПИЩЕВАРЕНИЯ У ДЕТЕЙ ПОСЛЕ ВИРУСНЫХ КИШЕЧНЫХ ИНФЕКЦИЙ

Objective: To study the intestinal microbiota in children with viral gastroenteritis (VG) and the role of dysbiosis in the genesis of functional pathology of the digestive system (FPDS). Materials and methods. 143 patients aged 1 to 7 years, without a history of gastroenterological diseases with moderate rotavirus, norovirus and the mixed company of norovirus-intestinal infections, verified by PCR in the feces were observed. Intestinal microbiota was evaluated using bacteriological method, real-time PCR and by the hydrogen breath test (study on the presence of bacterial overgrowth syndrome). Within 1 year of follow-up was carried out surveillance for the detection of functional disorders of the digestive system Results. During the acute period of RVI we revealed a significant decrease in Bacteroides thetaiataomicron and increase of Bacteroides fragilis comparing to the NVI. Proliferation of OP was observed in a quarter of patients with VG and accompanied by inflammatory changes in feces (more often for RNVI). FPDS diagnosed in 22.7% of convalescents VG, which rate was at RNVI 26.9%, RVI - 25.9%, NVI - 17.3%. Children who have formed FPDS showed in intestinal microbiota a trend toward reduction of Bifidobacterium spp., F. prausnitzii and increase B. fragilis. BOS diagnosed at all VI, with a maximum frequency at RNVI (54.5%). Revealed a connection BOS with the manifestation FPDS. Conclusion. Intestinal dysbiosis and bacterial overgrowth syndrome at VII pathogenically associated with the development of postinfectious FPDS in children.