Improved method for the diagnosis of acute coronary syndrome.

A method for diagnosing in vitro an acute coronary syndrome in a person by using as marker either PAPP-A Free, defined as plasma protein associated with pregnancy (PAPP-A) that is not complexed to the proform of major basic protein (proMBP), as such or as a ratio - PAPP-a free / PAPP-a total - PAPP-a free / PAPP-a complexed to proMBP, or - PAPP-a complexed to proMBP / PAPP -A total.