Alum Catalyzed Green Methodology For The Synthesis Of Substituted Pyrazole Curcumin Analogues

Curcumin is naturally occurring yellow pigments isolated from Curcuma longa, structurally it is polyphenolic compounds consisting spectacular biological activity. However, clinical utility of curcumin is limited due to its poor bioavailability. Synthesis of heterocyclic curcumin analogues is major attempt to overcome such limitations. Heterocyclic analogues of Curcumin prepared by one pot green methodology by using naturally occurring Alum [K, Al (SO4)2.12H2O] as catalyst. Both, conventional and microwave irradiation methods were found productive. In summary, present methodology offers rapid synthesis of pyrazole analogues of curcumin ins short course of time with many advantages like environmentally benign catalyst and solvent, cost effective, easy product separation and clean reaction profile