DNA repair, NFKβ, and TP53 polymorphisms associated with potentially malignant disorders and oral squamous cell carcinoma in Argentine patients

Abstract Objective An important strategy in cancer prevention is to identify individual susceptibilities for cancer development through the genomic profile. The developing countries such as Argentina has no data about genetic composition. The aim was to evaluate the single nucleotide polymorphisms of genes related to DNA repair (XCCR3, XPD), cell cycle arrest/apoptosis (TP53), and inflammation (NFKβ) of patients with pre-cancer and oral cancer, and to contribute to recognizing potential risk for developing these pathologies in Cordoba, Argentina. Study design A cross-sectional study was performed on 140 from patients with oral squamous cell carcinoma, orally potentially malignant disorders, and controls. The genotyping of SNP was performed using allele-specific PCR or RFLP techniques. The variables were evaluated by bivariate and multivariate statistical methods, setting p Results The multiple correspondence analyses showed that OSCC patients are clustered with the T allele of XRCC3 T241M and the C allele of TP53 R72P, while OPDM patients are clustered with the T allele of NFKβ-519. Conclusion Our preliminary results showed that the C allele of Pro72 variant of TP53 was related to OSSC and OPMD, while allele T of NFKβ-519 is related to OPMD in Argentine patients.