Ammoximation reaction and separation coupling process and device

The invention discloses an ammoximation reaction and separation coupling process which comprises the following steps: continuously adding reaction raw materials and a solvent in different groups outside a reaction kettle into a pipeline reactor for reaction, mixing the components in a mixer, and subsequently feeding the mixture into the reaction kettle for sufficient reaction, wherein the upper part of the reaction kettle is a reaction zone, and the lower part of the reaction kettle is a filtration separation zone; separating a reaction product, namely, cyclohexanone-oxime from a catalyst in the filtration separation zone, feeding the separated cyclohexanone-oxime into a later process, and circulating the catalyst back to the reaction kettle for continuous reaction through equipment such as the pipeline reactor outside the reaction kettle. Backwashing is performed once every 10-300 seconds, so that the continuity of reaction separation is ensured. As the raw materials sufficiently contact the catalyst, the reaction is complete, and the conversion rate of cyclohexanone can be 99.9-100%. The whole set of reaction separation devices is reasonable in arrangement and stable in reaction.