CLINIC-MORPHOLOGICAL FEATURES OF SYNCHRONIZATION OF INFLAMMATION IN A MUCOUS MEMBRANE OF A MIDDLE EAR IN MODERN CONDITIONS

Objective. To determine the clinical and morphological  criteria of chronic inflammation development in the middle ear mucosa and the study of local immunity. Material and methods . 67 patients  aged from 19 to 67 years (men-28,  women-39) with complaints of pain, congestion in the ear, constant or intermittent  mucopurulent discharge from the ear, and hearing loss were examined. The disease  duration ranged from 3 days to 20 years or more. We have investigated the mucosa of the pathologically changed parts of the tympanic cavity. The sections were  stained  with hematoxylin  and eosin,  and trichromatic color by Mallory. For the  immunohistochemical  study monoclonal antibodies  to T lymphocytes  (CD4 T-lymphocytes-helper cells, CD8 T-lymphocytes-suppressors), B-lymphocytes  (CD20) were used. The calculation of the immunohistochemical  reaction was performed with a standard increase of 40 in 12 fields of view. Conclusions . On Week 3 of the disease is a clear imbalance in the local immune defense occurs, which is a turning point in the course of the disease. In the period since 6 months and suppression of the immune response was detected. Thus, we believe that in conditions of a purulent inflammatory process the beginning of the process of chronic inflammation (development of granulation tissue) in the mucous membrane of the middle ear occurs on Week 3 from the onset of the disease, which is by 2–2.5  times later than in aseptic conditions.