Palladium-catalyzed synthesis of spirooxindoles and [3,4]-fused oxindoles from alkene-tethered carbamoyl chlorides

We disclosed an efficient Pd-catalyzed domino reaction for facile synthesis of spirooxindoles and [3,4]-fused oxindoles from alkene-tethered carbamoyl chlorides. The five-membered C,C-palladacycle obtained through intramolecular C–H activation should act as the key intermediate in both catalytic cycles. A variety of functionalized spirooxindoles and [3,4]-fused oxindoles were synthesized in moderate to good yields.