ROLE OF DEFLAZACORT AND TAMSULOSIN IN MEDICAL EXPULSIVE THERAPY FOR SYMPTOMATIC LOWER URETERIC STONES

colic is a common Urological emergency, Ureteroscopy with intra corporeal lithotripsy is a proven method of treatment and it is not free of complications. Recently medical expulsive therapy with drugs has been used which reduces the symptoms and helps in stone expulsion. We performed a randomized prospective study to evaluate the role of corticosteroid Deflazacort in combination with alpha blocker Tamsulosin in medical management of symptomatic lower ureteric stones of 5-10mm size. MATERIALS AND METHODS: Between 1st january 2014 to 31st december 2014 we enrolled 100 patients of symptomatic lower ureteric calculus of >5mm diameter in this prospective study and divided in to 3 groups. Group A 40 patients received Tamsulosin and Deflazacort, Group B 30 patients received only Tamsulosin and Group C 30 patients received only analgesics. The treatment duration was 30 days. The end point were stone expulsion rate, analgesic consumption and number of URSL and safety. RESULTS: All the groups were comparable in terms of age, sex, stone size and stone location. 85 patients completed the study. The rate of stone expulsion for 3 groups were 34/38(89%), 20/25(80%), 10/22(45%) respectively. Statistically significant difference was noted between groups A&B with respect to group C. The mean analgesic consumption was less in group A. No significant side effects were reported with these drugs. CONCLUSION: Deflazacort with Tamsulosin combination is proved to be efficient and has to be considered as first line of medical expulsive therapy in the management of symptomatic lower ureteric calculus. In addition Tamsulosin alone can be considered as alternative treatment for those not suitable for steroid