O3414 THE POTENTIAL INFLUENCE OF I-PARATHYROID HORMONE ON THE DEVELOPMENT OF SLIPPED CAPITAL FEMORAL EPIPHYSIS IN ADOLESCENTS

Aims: In order to assess the potential pathologic insuence of any Parathyroid Hormone (PTH) disturbances on the development of Slipped Capital Femoral Epiphysis (SCFE) during adolescence, we conducted a prospective clinical study. Methods: Nineteen patients in total were included in the study. Fourteen patients, 7 boys and 7 girls (16 hips), suffering from SCFE during the proceedings of this study, formed group OAO. Another 5 patients that had been treated for SCFE a few years before the study, were used as a control group (group OBO). We measured the level of I-PTH, along with serum Calcium (Ca) and Phosphorus (P) levels. Furthermore we checked all the necessary anthropometrical characteristics of the patients (age, height, weight and sexual maturation). Each patient of group OAO was categorized from grade I to grade V according to the progress of the slipping. Results: An increased incidence (9 out of 14 patients), of serum PTH level abnormalities (both decrease and increase) in group OAO was detected. Group OBO patients had normal results. It is interesting that the detected I-PTH serum level abnormalities were not in any pattern related to the Ca and P serum levels. Conclusions: We believe that a temporary Parathyroid Hormone disorder or imbalance (along with others etiologic factors) during the early years of adolescence, may play a potentially signiþcant role in the development of SCFE.