Estrogen Receptor Beta (erβ) in Endometrial Simple Hyperplasia and Endometrioid Carcinoma

Aims The aim of this study was to analyze the expression of estrogen receptor (ER) β in endometrioid carcinoma in comparison to non-neoplastic endometrium. Methods Fifty-seven histopathologically confirmed non-neoplastic endometria (22 proliferative phase, 15 secretory phase, and 20 simple hyperplasia without atypia), and 26 cases of endometrioid carcinoma were studied. The ERβ/ERα transcript ratio was determined by semiquantitative reverse transcription-polymerase chain reaction. The receptor protein expression was evaluated by immunohistochemistry using the Allred Scoring System. Results Decreased expression of ERβ, ERα, and progesterone receptor proteins was observed in endometrioid carcinoma compared with proliferative endometrium and simple hyperplasia (P Conclusions Thus, ERβ alterations are important in endometrioid carcinoma. The relationship of ERβ expression to myoinvasion warrants further investigation.