Fourier analysis of mitochondrial distribution in oocytes
2011
This paper describes a novel approach to quantifying mitochondrial patterns which are typically
described using the qualitative terms "diffuse" "aggregated" and are potentially key indicators
for an oocyte's health and survival potential post-implantation. An oocyte was isolated in a
confocal image and a coarse grid was superimposed upon it. The spatial spectrum was calculated
and an aggregation factor was generated. A classifier for healthy cells was developed and verified.
The aggregation factor showed a clear distinction between the healthy and unhealthy oocytes.
The ultimate goal is to screen oocytes for viability preimplantation, thus improving the outcome
of in vitro fertilization (IVF) treatments.
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