A New Potential Predictor of Coronary Artery Disease: The Ratio of Mitral Peak Filling Velocity to Mitral Annular Velocity in Early Diastole

: BACKGROUND The aim of this study was to explore the value of the ratio of mitral peak filling velocity (E) to mitral annular velocity (e') in early diastole as a predictor of coronary artery disease (CAD). MATERIAL AND METHODS The study population consisted of 83 consecutive patients (aged 38-77 years, 22 women and 61 men) who received coronary angiography. The E/e' ratio was estimated by echocardiographic examination. Statistical significance was determined by receiver operating characteristic (ROC) curve and multiple logistic regression analyses. RESULTS ROC curve analysis showed that the optimal E/e' ratio cut-off for predicting CAD was 8.153 with a specificity of 72.4% and sensitivity of 57.4%. The area under the ROC curve was 0.635 with a 95% confidence interval (CI) for normal distribution of 0.515-0.755 (p=0.043). Multivariate logistic regression analysis demonstrated that the E/e' ratio was closely associated with CAD (odds ratio [OR], 1.350; 95% CI, 1.087-1.676, p=0.007). CONCLUSIONS The E/e' ratio is a simple and practical predictor of CAD and may be an independent risk factor for CAD. Large-cohort and multi-center studies are required to confirm these observations.