Correlation between DDDs of levofloxacin and bacterial resistance in 2007-2010

OBJECTIVE To investigate the relationship between the DDDs of levofloxacin and antibiotic resistance of 10 main species of clinical isolates of pathogens so as to provide basis for the reasonable use of fluoroquinolones in the nospital.METHODS The clinical data of the patients who used 0.5 g of levofloxacin from Jan 2007 to Dec 2010 and the data of the drug resistance to levofloxacin of the 10 common species of pathogens isolated in the same period,were extracted,then the statistical analysis was performed with by using SPSS13.0 software.RESULTS From 2007 to 2010,Escherichia coli was the most common gram-negative bacterium with the isolation rate of 22.2%,following by Pseudomonas aeruginosus(15.9%) and Klebsiella spp(9.2 %).The drug resistance rates of the three species were highest in 2008,which were 71.6 %,49.4%,and 34.5%,respectively.At the same time,the DDDs of levofloxacin was 39.61.The DDDs of levofloxacin was highly positively correlated with the drug resistance rates of P.aeruginosa,Klebsiella spp,Staphylococcus aureus and Enterobacter(P0.05).CONCLUSION There is certain correlation between the DDDs of levofloxacin and bacterial resistance.