Alteration of photosensitizer content and parameters of free radical reactions in a patient blood under Photodynamic therapy of malignant tumors

The purpose of this study was to determine the changes in concentrations of the two Russian photosensitizers in blood plasma of patients under Photodynamic therapy. In this work were used two sensitizers of domestic production: Photohem (hematoporphyrine derivative, HPD) and Photosense (sulfonated aluminium phtalocyanine, AlPc). It was found that one month after injection the concentrations of the photosensitizers in blood plasma remained high enough. Was shown alteration of level of apo-β-lipoproteins oxidation and antioxidant activity of blood plasma under the influence of Photodynamic therapy.