Anti-thrombotic effect of very low doses of acetyl salicylic acid in rats

Abstract The anti-thrombotic effect of acetyl salicylic acid (ASA) was studied using the following experimental model : a silk thread was inserted in an extracorporeal shunt between the right carotid artery and the opposite jugular vein. A thrombus developed around the thread which was weighed at 10 minutes intervals. ASA inhibits the development of the thrombus at a dose of 3.1 mg/kg. When the dose was increased the anti-thrombotic effect disappeared. These results suggest that ASA may be an effective antithrombotic agent in man if the dosage is based on pharmacological data.