New lectin ligands: Testing of Amadori rearrangement products with a series of mannoside-specific lectins

Abstract 1-( N -Phenyl)amino-1-deoxy-α-D- manno -hept-2-ulose ( 2 ) and two multivalent BSA-based structures 7 and 8 , d - manno -configured C -glycosyl-type compounds derived from an Amadori rearrangement, were evaluated as ligands for mannoside-specific lectins of various sources. The determination of the concentration corresponding to 50% of inhibition (IC 50 ) is described. Multivalency turned out to effectively influence ligand selectivity and lectin binding.