PHARMACOKINETIC INTERACTIONS BETWEEN CLOPIDOGREL AND ROSUVASTATIN: EFFECTS ON VASCULAR PROTECTION IN SUBJECTS WITH CORONARY HEART DISEASE

Maria Cristina de Oliveira Izar,Pinheiro Lf,Carolina Nunes França,Simone P. Barbosa,Soraia H. Kasmas,Henrique Tria Bianco,Rui Póvoa,Francisco Antonio Helfenstein Fonseca

PHARMACOKINETIC INTERACTIONS BETWEEN CLOPIDOGREL AND ROSUVASTATIN: EFFECTS ON VASCULAR PROTECTION IN SUBJECTS WITH CORONARY HEART DISEASE

2012

Maria Cristina de Oliveira Izar
Pinheiro Lf
Carolina Nunes França
Simone P. Barbosa
Soraia H. Kasmas
Henrique Tria Bianco
Rui Póvoa
Francisco Antonio Helfenstein Fonseca

Genetic polymorphisms in the hepatic cytochrome P450 (CYP2C19) affect the antiplatelet effects of clopidogrel. Rosuvastatin is partially metabolized by the same cytochrome. We hypothesized that pharmacokinetic interactions between these drugs might affect their individual responses on vascular

Keywords:

Cytochrome P450
Clopidogrel
Cytochrome
Rosuvastatin
Diabetes mellitus
CYP2C19
Heart disease
Pharmacokinetics
Medicine
Internal medicine
Cardiology
hepatic cytochrome
coronary heart disease

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