Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

Shiran Rabinovich,Lital Adler,Keren Yizhak,Alona Sarver,Alon Silberman,Shani Agron,Noa Stettner,Qin Sun,Alexander Brandis,Daniel Helbling,Stanley H. Korman,Shalev Itzkovitz,David Dimmock,Igor Ulitsky,Sandesh C.S. Nagamani,Eytan Ruppin,Ayelet Erez

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

2015

Shiran Rabinovich
Lital Adler
Keren Yizhak
Alona Sarver
Alon Silberman
Shani Agron
Noa Stettner
Qin Sun
Alexander Brandis
Daniel Helbling
Stanley H. Korman
Shalev Itzkovitz
David Dimmock
Igor Ulitsky
Sandesh C.S. Nagamani
Eytan Ruppin
Ayelet Erez

ASS1, a urea cycle enzyme, promotes cancer cell proliferation by facilitating pyrimidine synthesis via CAD (carbamoyl-phosphate synthase 2, aspartate transcarbamylase, and dihydroorotase complex) activation.

Keywords:

Urea cycle
Argininosuccinate synthase
Cell growth
Aspartic acid
Pyrimidine metabolism
Aspartate carbamoyltransferase
Enzyme activator
Dihydroorotase
Biochemistry
Biology
ATP synthase

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