Effects of Quarterly Hormone Replacement Therapy on Climacteric Symptoms, Endometrial Safety, and Lipoproteins

A one-year double-blind randomized study in 80 healthy postmenopausal nonhysterectomized women was performed to investigate the effects of continuous estrogen supplementation sequentially combined with progestogen administration once every three months (once a quarter) compared with monthly progestogen administration on climacteric symptoms, bleeding pattern, endometrial histology, and lipoproteins.