Subtituted phenylthiophene benzoylsulfonamides with potent binding affinity to angiotensin II AT1 and AT2 receptors

Abstract Incorporation of a benzoylsulfonamide and a phenylthiophene group into the potent AII antagonist L-158,809 afforded compounds with a high affinity for the AT 1 receptor. Substitution at the 5′-position of the thiophene ring dramatically increased AT 2 binding affinity provinding an analog with equal affinity for both AT 1 and AT 2 receptors.