Anti-Peptide Immunocapture with In-Sample Calibration Curve Strategy for Sensitive and Robust LC-MS/MS Bioanalysis of Clinical Protein Biomarkers in Formalin-Fixed Paraffin-Embedded Tumor Tissues

Naiyu Zheng,Kristin Taylor,Huidong Gu,Rasa Santockyte,Xi Tao Wang,Jean McCarty,Olufemi Adelakun,Yan J Zhang,Renuka Pillutla,Jianing Zeng

Anti-Peptide Immunocapture with In-Sample Calibration Curve Strategy for Sensitive and Robust LC-MS/MS Bioanalysis of Clinical Protein Biomarkers in Formalin-Fixed Paraffin-Embedded Tumor Tissues

2020

Naiyu Zheng
Kristin Taylor
Huidong Gu
Rasa Santockyte
Xi Tao Wang
Jean McCarty
Olufemi Adelakun
Yan J Zhang
Renuka Pillutla
Jianing Zeng

Despite huge promises, bioanalysis of protein biomarkers in formalin-fixed paraffin-embedded (FFPE) tissues by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for clinical applications is...

Keywords:

tumor tissue
Bioanalysis
Mass spectrometry
protein biomarkers
formalin fixed paraffin embedded
Calibration curve
Chemistry
lc ms ms
Chromatography
Peptide

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