Leucine-derived cyanoglucosides from the aerial parts of Sorbaria sorbifolia (L.) A. Braun.

Abstract Six new cyanoglucosides, 2 S -cardiospermin-5-benzoate ( 1 ), 2 R -cardiospermin-5- p -hydroxybenzoate ( 2 ), 2 S -cardiospermin-5- cis - p -coumarate ( 3 ), isocardiospermin-5- p -hydroxybenzoate ( 4 ), sutherlandin-5- p -hydroxybenzoate ( 5 ), and sutherlandin-5- cis - p -coumarate ( 6 ), together with 17 known compounds were isolated from Sorbaria sorbifolia . The structures of the new compounds were elucidated by extensive spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS and ECD experiments. The biosynthetic relationship of 1 – 9 was also discussed. The cyanoglucosides ( 1 – 9 ) and 15 exhibited moderate inhibitory effect on nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS).