Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in $\small \textit{BRCA1}$ and $\small \textit{BRCA2}$ Mutation Carriers

Elena Vigorito,Karoline B. Kuchenbaecker,Jonathan Beesley,Julian Adlard,Bjarni A. Agnarsson,Irene L. Andrulis,Banu K Arun,Laure Barjhoux,Muriel Belotti,Javier Benitez,Andreas Berger,Anders Bojesen,Bernardo Bonanni,Carole Brewer,Trinidad Caldés,Maria-Adelaide Caligo,Ian G. Campbell,Salina B. Chan,Kathleen Claes,David E. Cohn,Jackie Cook,Mary B. Daly,Francesca Damiola,Rosemarie Davidson,Antoine de Pauw,Capucine Delnatte,Orland Diez,Susan M. Domchek,Martine Dumont,Katarzyna Durda,Bernd Dworniczak,Douglas F. Easton,Diana Eccles,Ardnor Christina Edwinsdotter,Ros Eeles,Bent Ejlertsen,Stephen David Ellis,D. Gareth Evans,Lidia Feliubadaló,Florentia Fostira,William D. Foulkes,Eitan Friedman,Debra Frost,Pragna Gaddam,Patricia A. Ganz,Judy Garber,Vanesa Garcia-Barberan,Marion Gauthier-Villars,Andrea Gehrig,Anne-Marie Gerdes,Sophie Giraud,Andrew K. Godwin,David E. Goldgar,Christopher R. Hake,Thomas V O Hansen,Sue Healey,Shirley Hodgson,Frans B. L. Hogervorst,Claude Houdayer,Peter J. Hulick,Evgeny N. Imyanitov,Claudine Isaacs,Louise Izatt,Ángel Izquierdo,Lauren Jacobs,Anna Jakubowska,Ramunas Janavicius,Katarzyna Jaworska-Bieniek,Uffe Birk Jensen,Esther M. John,Joseph Vijai,Beth Y. Karlan,Karin Kast,kConFab Investigators,Sofia Khan,Ava Kwong,Yael Laitman,Jenny Lester,Fabienne Lesueur,Annelie Liljegren,Jan Lubinski,Phuong L. Mai,Siranoush Manoukian,Sylvie Mazoyer,Alfons Meindl,Arjen R. Mensenkamp,Marco Montagna,Katherine L. Nathanson,Susan L. Neuhausen,Heli Nevanlinna,Dieter Niederacher,Edith Olah,Olufunmilayo I. Olopade,Kai-ren Ong,Ana Osorio,Sue K. Park,Ylva Paulsson-Karlsson,Inge Søkilde Pedersen,Bernard Peissel,Paolo Peterlongo,Georg Pfeiler,Catherine M. Phelan,Marion Piedmonte,Bruce Poppe,Miquel Angel Pujana,Paolo Radice,Gad Rennert,Gustavo C. Rodriguez,Matti A. Rookus,Eric A. Ross,Rita K. Schmutzler,Jacques Simard,Christian F. Singer,Thomas P. Slavin,Penny Soucy,Melissa C. Southey,Doris Steinemann,Dominique Stoppa-Lyonnet,Grzegorz Sukiennicki,Christian Sutter,Csilla Szabo,Muy-Kheng Tea,Manuel R. Teixeira,Soo Hwang Teo,Mary Beth Terry,Mads Thomassen,Maria Grazia Tibiletti,Laima Tihomirova,Silvia Tognazzo,Rensburg Elizabeth J van,Liliana Varesco,Raymonda Varon-Mateeva,Athanassios Vratimos,Jeffrey N. Weitzel,Lesley McGuffog,Judy Kirk,Amanda Ewart Toland,Ute Hamann,Noralane Morey Lindor,Susan J. Ramus,Mark H. Greene,Fergus J. Couch,Kenneth Offit,Paul Pharoah,Georgia Chenevix-Trench,Antonis C. Antoniou

Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in $\small \textit{BRCA1}$ and $\small \textit{BRCA2}$ Mutation Carriers

2016

Elena Vigorito
Karoline B. Kuchenbaecker
Jonathan Beesley
Julian Adlard
Bjarni A. Agnarsson
Irene L. Andrulis
Banu K Arun
Laure Barjhoux
Muriel Belotti
Javier Benitez
Andreas Berger
Anders Bojesen
Bernardo Bonanni
Carole Brewer
Trinidad Caldés
Maria-Adelaide Caligo
Ian G. Campbell
Salina B. Chan
Kathleen Claes
David E. Cohn
Jackie Cook
Mary B. Daly
Francesca Damiola
Rosemarie Davidson
Antoine de Pauw
Capucine Delnatte
Orland Diez
Susan M. Domchek
Martine Dumont
Katarzyna Durda
Bernd Dworniczak
Douglas F. Easton
Diana Eccles
Ardnor Christina Edwinsdotter
Ros Eeles
Bent Ejlertsen
Stephen David Ellis
D. Gareth Evans
Lidia Feliubadaló
Florentia Fostira
William D. Foulkes
Eitan Friedman
Debra Frost
Pragna Gaddam
Patricia A. Ganz
Judy Garber
Vanesa Garcia-Barberan
Marion Gauthier-Villars
Andrea Gehrig
Anne-Marie Gerdes
Sophie Giraud
Andrew K. Godwin
David E. Goldgar
Christopher R. Hake
Thomas V O Hansen
Sue Healey
Shirley Hodgson
Frans B. L. Hogervorst
Claude Houdayer
Peter J. Hulick
Evgeny N. Imyanitov
Claudine Isaacs
Louise Izatt
Ángel Izquierdo
Lauren Jacobs
Anna Jakubowska
Ramunas Janavicius
Katarzyna Jaworska-Bieniek
Uffe Birk Jensen
Esther M. John
Joseph Vijai
Beth Y. Karlan
Karin Kast
kConFab Investigators
Sofia Khan
Ava Kwong
Yael Laitman
Jenny Lester
Fabienne Lesueur
Annelie Liljegren
Jan Lubinski
Phuong L. Mai
Siranoush Manoukian
Sylvie Mazoyer
Alfons Meindl
Arjen R. Mensenkamp
Marco Montagna
Katherine L. Nathanson
Susan L. Neuhausen
Heli Nevanlinna
Dieter Niederacher
Edith Olah
Olufunmilayo I. Olopade
Kai-ren Ong
Ana Osorio
Sue K. Park
Ylva Paulsson-Karlsson
Inge Søkilde Pedersen
Bernard Peissel
Paolo Peterlongo
Georg Pfeiler
Catherine M. Phelan
Marion Piedmonte
Bruce Poppe
Miquel Angel Pujana
Paolo Radice
Gad Rennert
Gustavo C. Rodriguez
Matti A. Rookus
Eric A. Ross
Rita K. Schmutzler
Jacques Simard
Christian F. Singer
Thomas P. Slavin
Penny Soucy
Melissa C. Southey
Doris Steinemann
Dominique Stoppa-Lyonnet
Grzegorz Sukiennicki
Christian Sutter
Csilla Szabo
Muy-Kheng Tea
Manuel R. Teixeira
Soo Hwang Teo
Mary Beth Terry
Mads Thomassen
Maria Grazia Tibiletti
Laima Tihomirova
Silvia Tognazzo
Rensburg Elizabeth J van
Liliana Varesco
Raymonda Varon-Mateeva
Athanassios Vratimos
Jeffrey N. Weitzel
Lesley McGuffog
Judy Kirk
Amanda Ewart Toland
Ute Hamann
Noralane Morey Lindor
Susan J. Ramus
Mark H. Greene
Fergus J. Couch
Kenneth Offit
Paul Pharoah
Georgia Chenevix-Trench
Antonis C. Antoniou

Cancer Research UK (Grant IDs: C12292/A11174, C1287/A10118), Medical Research Council (Advanced Studentship award)

Keywords:

BRCA2 Mutation
Medical research
Ovarian cancer
Genome-wide association study
Allele
Meta-analysis
Genetics
Biology
Mutation

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