Preparation and Characterization of Magnetic Aclacinomycin-A Nanoparticles

Purpose The objective of this study is to prepare magnetic nanoparicles for drug delivery system with polybutylcyanoacrylate(PBCA)and aclacinomycin A (ACM-A). Methods Magnetic PBCA nanospheres loaded with ACM and Fe 3O 4 nanoparticle were prepared by interfacial polymerization and reverse-phase microemulsion.The structure of this polymer,loading rate and embedding ratio were confirmed by SEM,TEM,DLS and vibrating-sample magnetometer(VSM). Results The drug's loading rate was 10.0%,embedding ratio was 36.2% and the mean particle size was 210 nm.Various parameters including amount of monomer,organic solvent,the kind of surfactants、ratio of oil/water phase and reaction temperature,could affect the particle size and the entrapment of the M-ACM-PBCA-NP. Conclusions M-ACM-PBCA-NP responded well to the applied magnetic field and M-ACM-PBCA-NP was an efficient new carrier of ACM by magnetic mechanisms.