운동 빈도의 차이가 노화된 흰쥐 골격근 내 autophagy factors의 발현에 미치는 영향

The purpose of this sutyd was to investigate the effects of exercise frequency different on expression of autophagic markers in aged rats skeletal muscle. Divide into six groups: young control (YC group, n=5), young exercise 3days/week (YE3 group, n=7), young exercise 5days/week (YE5 group, n=7), old control (OC group, n=6), old exercise 3days/week (OE3 group, n=5), old exercise 5days/week (OE5 group, n=6) on a treadmill run with an intensity of 21m/min, 10° incline during 6 weeks. After exercise training, expression of the Atg5/12, Beclin 1, Atg7, Cathepsin L (CTSL) levels were increased significantly in both OE3 and OE5 groups. In contrast, LC3=Ⅱ and p62 levels were decreased significantly in the exercise groups in both OE3 and OE5. The major finding of this study was that OE5 groups contribute to enhance autophagic signaling pathway in aged skeletal muscle than in OE3 groups.