10-hydroxyevodiamine type anti-tumor compounds as well as preparation method and application thereof

The invention relates to 10-hydroxyevodiamine type anti-tumor compounds, a preparation method of the 10-hydroxyevodiamine type anti-tumor compounds and an application of the 10-hydroxyevodiamine type anti-tumor compounds in preparing an anti-tumor drug. The 10-hydroxyevodiamine type anti-tumor compounds have a structure shown in the formula I. The compounds are newly found topoisomerase inhibitors with brand new structures, most of compounds have broad-spectrum antitumor activity, and the IC50 (half maximal inhibitory concentration) of a part of derivatives to tested three tumors is smaller than 0.001 mu g/mL and is superior to that of compounds (10-hydroxyevodiamine) with similar structures and best activity in the prior art.