Reply to “Tolerogenic insulin peptide therapy precipitates type 1 diabetes”

In this issue of JEM, Bergman et al. ( ) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3+ regulatory T cell conversion.