2P-110 : Combination cancer treatment using chemo-photodynamic therapy based on BSA nanoparticles

Chemotherapy is commonly used in cancer therapy. However, chemotherapy alone has many side effects such as development of drug resistance. In this work, we developed the biodegradable nanomaterial for combination therapy for effective anti-cancer agent. Bovine serum albumin-based nanoparticles (BNPs) have excellent suitable properties to use drug delivery system. An anti-tumor drug (doxorubicin) and a photosensitizer (Chlorin e6) for photodynamic therapy were co-loaded in BNPs to obtain effective combination anti-cancer agent nanoparticles (Ce6/DOX/BNPs). And folic acid (FA) was used for cancer cell targeting (FA-Ce6/DOX/BNPs). The characterization of FA-Ce6/DOX/BNPs were studied by fluorescence spectrum, Fourier transform infrared spectrum. The FA-Ce6/DOX/BNPs produced excessive ROS under 671-nm laser exposure and induced mitochondrial membrane damage. The anticancer effect of combination therapy with FA-Ce6/DOX/BNPs was higher than chemotherapy alone and had fewer side effects.