[Correlation between SUV of (18)F-FDG PET-CT and the expression of GLUT1, MVD and Ki67 in non-small cell lung cancer].

Objective To investigate the correlation between ^18F-FDG standard uptake value （SUV） and expression of GLUTI, MVD and Ki67 in non-small cell lung cancer （NSCLC）. Methods Thirty-three patients with non-small cell lung cancer received preoperative ^18F-FDG PET-CT examination and underwent surgery. The expression of GLUT1, MVD and Ki67 were detected by immunohistochemstry. The correlation between the SUV of ^18F-FDG PET-CT and the immunohistochemical results of the three above mentioned parameters was analyzed. Results Of the 33 NSCLC patients, 21 were in stage Ⅰ , 4 in stage Ⅱ and 8 in stage Ⅲ a. Positive expression of GLUT1 was found in 22 cases （66.7% , 12 adenocarcinomas and 10 squamous cell carcinomas）, and negative expression in 11 cases （10 adenocarcinomas and 1 squamous cell carcinoma）. Twenty-four patients （72.7%） showed positive expression of Ki67 （ 13 adenocarcinomas and 11 squamous cell carcinomas ）, and other 9 （adenocarcinomas） had negative expression. The positive expression rate of CD34 in this series was 100.0% with a mean MVD of 12.6 ± 2.9. Conclusion SUV of ^18F-FDG PET-CT is linearly correlated with the expression of GLUT1, but not with the expression of Ki67 or MVD. The expression of GLUT1, Ki67 and CD34 is not correlated with tumor size and lymph node metastasis. Key words: Lung neoplasms;  PET/CT;  Lung neoplasms;  PET/CT;  ^18F-FDG;  SUV;  Tumoral molecular-biological indexF-FDG;  SUV;  Tumoral molecular-biological index