Liver fibrosis and all-cause mortality in chronic HCV-infected diabetic patients: a paradoxical association? (ANRS CO22 HEPATHER).

We read with great interest the article published by Ciancio et al., which reported long-term improvement of glycometabolic control in diabetic patients with chronic hepatitis C following sustained virological response with direct-acting antivirals (DAA) (1). They also reported a detrimental effect of baseline diabetes on hepatocellular carcinoma (HCC) incidence in cirrhotic hepatitis C patients after multiple adjustment, and a higher mortality rate in hepatitis C patients with diabetes than in their non-diabetic counterparts.